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Article

DNA methylation mediates persistent epileptiform activity in vitro and in vivo.

PloS one - 1 Jan 2013

Machnes Ziv M, Huang Tony C T, Chang Philip K Y, Gill Raminder, Reist Nicholas, Dezsi Gabriella, Ozturk Ezgi, Charron Francois, O'Brien Terence J, Jones Nigel C, McKinney R Anne, Szyf Moshe

Abstract excerpt

Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms that link the transient neuronal insult to the lasting state of epilepsy are unknown. Here we tested the possible role of DNA methylation in mediating long-term induction of epileptiform activity by transient kainic acid exposure using in vitro and in vivo rodent models. We analyzed...

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Identifiers

PMID: 24098468
DOI: 10.1371/journal.pone.0076299
PMCID: PMC3788713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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