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Article

Genetic background influences susceptibility to chemotherapy-induced hematotoxicity.

The pharmacogenomics journal - 1 Apr 2018

Gatti D M, Weber S N, Goodwin N C, Lammert F, Churchill G A

Abstract excerpt

Hematotoxicity is a life-threatening side effect of many chemotherapy regimens. Although clinical factors influence patient responses, genetic factors may also play an important role. We sought to identify genomic loci that influence chemotherapy-induced hematotoxicity by dosing Diversity Outbred mice with one of three chemotherapy drugs; doxorubicin, cyclophosphamide or docetaxel. We observed that each drug had...

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Identifiers

PMID: 28607509
DOI: 10.1038/tpj.2017.23
PMCID: PMC5729066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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