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Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity.

Oxidative medicine and cellular longevity - 1 Jan 2022

Ding Yonghe, Du Ke, Niu Yu-Juan, Wang Yong, Xu Xiaolei

Abstract excerpt

Anthracyclines are chemotherapeutic agents widely used to treat a variety of cancers, and these drugs have revolutionized our management of cancer patients. The dose-dependent cardiotoxicity of anthracyclines, however, remains one of the leading causes of chemotherapy treatment-associated mortality in cancer survivors. Patient threshold doses leading to anthracycline-induced cardiotoxicity (AIC) are highly...

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Anthracyclines
Antibiotics, Antineoplastic
Antineoplastic Agents
Cancer Treatment and Pharmacology
Cardiotoxicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chemotherapy-induced cardiotoxicity and mitigation

Genetic Predisposition to Disease

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Identifiers

PMID: 35965684
DOI: 10.1155/2022/5818612
PMCID: PMC9365594

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