Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using Drosophila melanogaster to identify chemotherapy toxicity genes.

Genetics - 1 Sept 2014

King Elizabeth G, Kislukhin Galina, Walters Kelli N, Long Anthony D

Abstract excerpt

The severity of the toxic side effects of chemotherapy shows a great deal of interindividual variability, and much of this variation is likely genetically based. Simple DNA tests predictive of toxic side effects could revolutionize the way chemotherapy is carried out. Due to the challenges in identifying polymorphisms that affect toxicity in humans, we use Drosophila fecundity following oral exposure to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboplatin
Share to Deoxycytidine
Share to Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gemcitabine

Share to Mitomycin

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

Share to Ribonucleoside Diphosphate Reductase

Source

Open in PubMed Open full text

Identifiers

PMID: 25236447
DOI: 10.1534/genetics.114.161968
PMCID: PMC4174942

Genes

ABCC2
MSH2
NALCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using Drosophila melanogaster to identify chemotherapy toxicity genes.PMID 25236447Read ↗

The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.Semantic proximity Read ↗

Genome-wide discovery of loci influencing chemotherapy cytotoxicitySemantic proximity Read ↗

Pharmacogenomic Characterization of US FDA-approved Cytotoxic DrugsSemantic proximity Read ↗

From Genes to Personalized Cancer Care: A Systematic Review of Toxicity-Associated Genetic Variants in Solid Tumor TreatmentsSemantic proximity Read ↗

Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.Semantic proximity Read ↗

Genome-wide association analysis of radiation resistance in Drosophila melanogaster.Semantic proximity Read ↗

Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populationsSemantic proximity Read ↗

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure.Semantic proximity Read ↗

Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity.Semantic proximity Read ↗

The use of genomic information to optimize cancer chemotherapy.Semantic proximity Read ↗

Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole.Semantic proximity Read ↗

Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical PracticeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.