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Article

A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.

Archives of biochemistry and biophysics - 15 Aug 2016

Liu Yu, Zhang Lei, Shao Xiao-Xia, Hu Meng-Jun, Liu Ya-Li, Xu Zeng-Guang, Guo Zhan-Yun

Abstract excerpt

Relaxin-3 is an insulin/relaxin superfamily neuropeptide involved in the regulation of food intake and stress response via activation of its cognate receptor RXFP3, an A-class G protein-coupled receptor (GPCR). In recent studies, a highly conserved ExxxD motif essential for binding of relaxin-3 has been identified at extracellular end of the second transmembrane domain (TMD2) of RXFP3. For most of the A-class...

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Identifiers

PMID: 27353281
DOI: 10.1016/j.abb.2016.06.013

Genes

RXFP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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