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Article

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting.

Nucleic acids research - 6 Sept 2017

Patiño-Parrado Iris, Gómez-Jiménez Álvaro, López-Sánchez Noelia, Frade José M

Abstract excerpt

Imprinted genes are regulated by allele-specific differentially DNA-methylated regions (DMRs). Epigenetic methylation of the CpGs constituting these DMRs is established in the germline, resulting in a 5-methylcytosine-specific pattern that is tightly maintained in somatic tissues. Here, we show a novel epigenetic mark, characterized by strand-specific hemimethylation of contiguous CpG sites affecting the germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28605464
DOI: 10.1093/nar/gkx518
PMCID: PMC5587773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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