Article

Development of a locus-specific HRM assay for DNA methylation analysis of the SHANK3 gene

2025-09-08

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation within CpG islands is a key epigenetic mechanism regulating gene expression. SHANK3 encodes a synaptic scaffolding protein essential for neurodevelopment and synaptic function, and aberrant SHANK3 methylation has been implicated in neuropsychiatric disorders. To enable reliable locus-specific investigation of SHANK3 epigenetic regulation, we developed a high-resolution melting (H...

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Literature Corpus work: f1ce0b07-b48a-55f3-b74b-ed3acdc3f9dc
DOI: 10.1101/2025.09.03.673955

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