Article
Spatial, temporal and interindividual epigenetic variation of functionally important DNA methylation patterns.
Nucleic acids research - 1 Jul 2010
Schneider Eberhard, Pliushch Galyna, El Hajj Nady, Galetzka Danuta, Puhl Alexander, Schorsch Martin, Frauenknecht Katrin, Riepert Thomas, Tresch Achim, Müller Annette M, Coerdt Wiltrud, Zechner Ulrich, Haaf Thomas
Abstract excerpt
DNA methylation is an epigenetic modification that plays an important role in gene regulation. It can be influenced by stochastic events, environmental factors and developmental programs. However, little is known about the natural variation of gene-specific methylation patterns. In this study, we performed quantitative methylation analyses of six differentially methylated imprinted genes (H19, MEG3, LIT1, NESP55,...
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