Article
Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair.
Molecular cell - 6 Jul 2017
Mazina Olga M, Keskin Havva, Hanamshet Kritika, Storici Francesca, Mazin Alexander V
Abstract excerpt
RNA can serve as a template for DNA double-strand break repair in yeast cells, and Rad52, a member of the homologous recombination pathway, emerged as an important player in this process. However, the exact mechanism of how Rad52 contributes to RNA-dependent DSB repair remained unknown. Here, we report an unanticipated activity of yeast and human Rad52: inverse strand exchange, in which Rad52 forms a complex with...
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