Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture.

The EMBO journal - 29 Nov 2006

Sugiyama Tomohiko, Kantake Noriko, Wu Yun, Kowalczykowski Stephen C

Abstract excerpt

Rad51, Rad52, and RPA play central roles in homologous DNA recombination. Rad51 mediates DNA strand exchange, a key reaction in DNA recombination. Rad52 has two distinct activities: to recruit Rad51 onto single-strand (ss)DNA that is complexed with the ssDNA-binding protein, RPA, and to anneal complementary ssDNA complexed with RPA. Here, we report that Rad52 promotes annealing of the ssDNA strand that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Single-Stranded
Share to SSB gene
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to Recombination, Genetic

Share to Replication Protein A

Source

Open in PubMed Open full text

Identifiers

PMID: 17093500
DOI: 10.1038/sj.emboj.7601412
PMCID: PMC1679760

Genes

SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture.PMID 17093500Read ↗

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes.Semantic proximity Read ↗

The recombination-deficient mutant RPA (rfa1-t11) is displaced slowly from single-stranded DNA by Rad51 protein.Semantic proximity Read ↗

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair.Semantic proximity Read ↗

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.Semantic proximity Read ↗

Human and yeast Rad52 proteins promote DNA strand exchange.Semantic proximity Read ↗

Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51.Semantic proximity Read ↗

The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing.Semantic proximity Read ↗

Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA.Semantic proximity Read ↗

Vital roles of the second DNA-binding site of Rad52 protein in yeast homologous recombination.Semantic proximity Read ↗

RAD51-independent inverted-repeat recombination by a strand-annealing mechanism.Semantic proximity Read ↗

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealingSemantic proximity Read ↗

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.