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Genetic variations in base excision repair genes and the risk of developing hepatoblastoma: A five-center case-control study from East China.

Cancer genetics - 1 Jun 2026

Shao Bo, Yin Huimin, Zhang Shouhua, He Shaohua, Lu Hongting, Fang Yuan, Zhou Chunlei

Abstract excerpt

BACKGROUND: Hepatoblastoma (HB) is the most common primary liver malignancy in children. Oxidative DNA damage is primarily repaired through the base excision repair (BER) pathway, and genetic polymorphisms in BER-related genes may influence individual susceptibility to HB. However, the contribution of BER gene variants to HB risk remains unclear. METHODS: A multicenter case-control study including 193 HB patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41844453
DOI: 10.1016/j.cancergen.2026.03.003

Genes

XRCC1
APEX1
PARP1
LIG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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