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The association of six polymorphisms of five genes involved in three steps of nucleotide excision repair pathways with hepatocellular cancer risk.

Oncotarget - 12 Apr 2016

Wang Bengang, Xu Qian, Yang Huai-Wei, Sun Li-Ping, Yuan Yuan

Abstract excerpt

BACKGROUND: Hundreds of single nucleotide polymorphisms (SNPs) of the genes encoding nucleotide excision repair (NER) proteins are involved in every step of the DNA recognition-unwinding-incision process, which may affect cancer risk. However, only a limited number of studies have examined the association of NER SNPs with hepatocellular cancer (HCC) risk. RESULTS: In screening stage, single-locus analysis showed...

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Biomarkers, Tumor
Carcinoma, Hepatocellular
Case-Control Studies
DNA Repair
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 26967386
DOI: 10.18632/oncotarget.7952
PMCID: PMC4991460

Genes

XPC
ERCC1
ERCC2
ERCC5
XPA
DDB2
ERCC3
ERCC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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