Article
Genetic variations in DNA-repair genes (XRCC1, 3, and 7) and the susceptibility to hepatocellular carcinoma in a cohort of Egyptians.
Journal of medical virology - 1 Dec 2020
Aboul Enein Azza Ahmed, Khaled Iman Abdel Aziz, Khorshied Mervat Mamdooh, Abdel-Aziz Ashraf Omar, Zahran Nariman, El Saeed Asmaa Mohamed, Shousha Hend Ibrahim, Abdel Rahman Hala Aly
Abstract excerpt
Chronic hepatitis C (CHC) is a worldwide etiology of chronic hepatic insult particularly in Egypt. DNA-repair systems are responsible for maintaining genomic integrity by countering threats posed by DNA lesions. Deficiency in the repair capacity due to genetic alterations in DNA-repair genes can lead to genomic instability and increased risk of cancer development. The present work aimed at studying the possible...
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