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Article

Requirement for LIM kinases in acute myeloid leukemia.

Leukemia - 1 Dec 2020

Jensen Patrizia, Carlet Michela, Schlenk Richard F, Weber Andrea, Kress Jana, Brunner Ines, Słabicki Mikołaj, Grill Gregor, Weisemann Simon, Cheng Ya-Yun, Jeremias Irmela, Scholl Claudia, Fröhling Stefan

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive disease for which only few targeted therapies are available. Using high-throughput RNA interference (RNAi) screening in AML cell lines, we identified LIM kinase 1 (LIMK1) as a potential novel target for AML treatment. High LIMK1 expression was significantly correlated with shorter survival of AML patients and coincided with FLT3 mutations, KMT2A rearrangements, and...

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Identifiers

PMID: 32591645
DOI: 10.1038/s41375-020-0943-5
PMCID: PMC7612252

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