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Article

Cellular signaling and epigenetic regulation of gene expression in leukemia

5 Oct 2019

Abstract excerpt

Alterations in normal regulation of gene expression is one of the key features of hematopoietic malignancies. In order to gain insight into the mechanisms that regulate gene expression in these diseases, we dissected the role of the Ikaros protein in leukemia. Ikaros is a DNA-binding, zinc finger protein that functions as a transcriptional regulator and a tumor suppressor in leukemia. The use of ChIP-seq,...

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PMID: 31623972
DOI: 10.1016/j.jbior.2019.100665

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