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Article

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies.

British journal of cancer - 11 Jul 2017

Alvi Muhammad A, Loughrey Maurice B, Dunne Philip, McQuaid Stephen, Turkington Richard, Fuchs Marc-Aurel, McGready Claire, Bingham Victoria, Pang Brendan, Moore Wendy, Maxwell Perry, Lawler Mark, James Jacqueline A, Murray Graeme I, Wilson Richard H, Salto-Tellez Manuel

Abstract excerpt

BACKGROUND: Signet ring cell colorectal cancer (SRCCa) has a bleak prognosis. Employing molecular pathology techniques we investigated the potential of precision medicine in this disease. METHODS: Using test (n=26) and validation (n=18) cohorts, analysis of mutations, DNA methylation and transcriptome was carried out. Microsatellite instability (MSI) status was established and immunohistochemistry (IHC) was used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28595259
DOI: 10.1038/bjc.2017.168
PMCID: PMC5520517

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BRAF
KIT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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