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Article

The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells.

IUBMB life - 1 Mar 2025

Li Yunlong, Jiang Xunliang, Cao Hui, Wu Xiao, Zhang Huimin, Ma Hongjiang, Wang Liangbo, Kang Boyu, Xie Mianjiao, Li Shisen

Abstract excerpt

The cGAS-STING signaling pathway has emerged as a critical player in the immune response against cancer, including colorectal adenocarcinoma (COAD). Understanding the impact of this pathway on COAD at multiple omics levels is crucial for advancing cancer immunotherapy and precision medicine. This study aimed to investigate the relationship between cGAS-STING-related genes and COAD, analyzing gene mutations, copy...

Read the complete abstract on PubMed

Topics

Humans
Membrane Proteins
Nucleotidyltransferases
Prognosis
Colorectal Neoplasms
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

DNA Copy Number Variations

Mutation

Caspase 8

Biomarkers, Tumor

Signal Transduction

Receptor-Interacting Protein Serine-Threonine Kinases

Adenocarcinoma

Female

Male

Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

STING Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 40035384
DOI: 10.1002/iub.70009
PMCID: PMC11877623

Genes

AIM2
CASP1
CASP8
CXCL10
NLRC3
RIPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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