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Article

Immune microenvironmental heterogeneity according to tumor DNA methylation phenotypes in microsatellite instability-high colorectal cancers.

Cancer immunology, immunotherapy : CII - 5 Sept 2024

Kim Jung Ho, Hong Jiyun, Lee Ji Ae, Jung Minsun, Choi Eunwoo, Cho Nam-Yun, Kang Gyeong Hoon, Kim Sangwoo

Abstract excerpt

The detailed association between tumor DNA methylation, including CpG island methylation, and tumor immunity is poorly understood. CpG island methylator phenotype (CIMP) is observed typically in sporadic colorectal cancers (CRCs) with microsatellite instability-high (MSI-H). Here, we investigated the differential features of the tumor immune microenvironment according to CIMP status in MSI-H CRCs. CIMP-high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39235590
DOI: 10.1007/s00262-024-03805-3
PMCID: PMC11377388

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