Article
Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake.
Science translational medicine - 7 Jun 2017
Liang Frank, Lindgren Gustaf, Sandgren Kerrie J, Thompson Elizabeth A, Francica Joseph R, Seubert Anja, De Gregorio Ennio, Barnett Susan, O'Hagan Derek T, Sullivan Nancy J, Koup Richard A, Seder Robert A, Loré Karin
Abstract excerpt
The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a model to delineate the steps of how adjuvant-driven innate immune activation leads to priming of vaccine responses using rhesus macaques. Fluorescently labeled HIV-1 envelope glycoprotein (Env) was administered together with the conventional aluminum salt...
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