Article
Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015
Lofano Giuseppe, Mancini Francesca, Salvatore Giulia, Cantisani Rocco, Monaci Elisabetta, Carrisi Corrado, Tavarini Simona, Sammicheli Chiara, Rossi Paccani Silvia, Soldaini Elisabetta, Laera Donatello, Finco Oretta, Nuti Sandra, Rappuoli Rino, De Gregorio Ennio, Bagnoli Fabio, Bertholet Sylvie
Abstract excerpt
Induction of persistent protective immune responses is a key attribute of a successful vaccine formulation. MF59 adjuvant, an oil-in-water emulsion used in human vaccines, is known to induce persistent high-affinity functional Ab titers and memory B cells, but how it really shapes the Ag-specific B cell compartment is poorly documented. In this study, we characterized the Ab- and Ag-specific B cell compartment in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.