Article
Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques.
Molecular therapy : the journal of the American Society of Gene Therapy - 6 Dec 2017
Liang Frank, Lindgren Gustaf, Lin Ang, Thompson Elizabeth A, Ols Sebastian, Röhss Josefine, John Shinu, Hassett Kimberly, Yuzhakov Olga, Bahl Kapil, Brito Luis A, Salter Hugh, Ciaramella Giuseppe, Loré Karin
Abstract excerpt
mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on precise but adaptable antigen design. We show that two immunizations of modified non-replicating mRNA encoding influenza H10 hemagglutinin (HA) and encapsulated in lipid nanoparticles (LNP) induce protective HA inhibition titers and H10-specific CD4+ T cell...
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