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Article

Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes.

Journal of virology - 1 Jun 2010

Kaufman David R, Bivas-Benita Maytal, Simmons Nathaniel L, Miller Darby, Barouch Dan H

Abstract excerpt

Candidate HIV-1 vaccine regimens utilizing intramuscularly (i.m.) administered recombinant adenovirus (rAd)-based vectors can induce potent mucosal cellular immunity. However, the degree to which mucosal rAd vaccine routing might alter the quality and anatomic distribution of vaccine-elicited CD8(+) T lymphocytes remains unclear. We show that the route of vaccination critically impacts not only the magnitude but...

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Share to Adenoviridae
Share to Administration, Intranasal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AIDS Vaccines

Share to Antibodies, Viral

Share to CD8-Positive T-Lymphocytes

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Share to Injections, Intramuscular

Source

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Identifiers

PMID: 20357087
DOI: 10.1128/JVI.02563-09
PMCID: PMC2876628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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