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Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Adjuvants are immuno-activators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses; the latter being indispensable for protection against intracellular pathogens and cancer. Here, we iteratively optimized...

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Literature Corpus work
106cc72c-ef0f-59e5-9d64-5623cbdcb09f
DOI
10.1101/2024.11.01.621501
Open publication

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Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primatesDOI 10.1101/2024.11.01.621501
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