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Article

Rational design of small molecules as vaccine adjuvants

19 Nov 2014

Abstract excerpt

Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvant safety because of a poor understanding of adjuvant mechanism and the empirical nature of adjuvant discovery and development historically. We describe new principles...

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Identifiers

PMID: 25411473
DOI: 10.1126/scitranslmed.3009980

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