Article
Comparison of human and rhesus macaque T-cell responses elicited by boosting with NYVAC encoding human immunodeficiency virus type 1 clade C immunogens.
Journal of virology - 1 Jun 2009
Mooij Petra, Balla-Jhagjhoorsingh Sunita S, Beenhakker Niels, van Haaften Patricia, Baak Ilona, Nieuwenhuis Ivonne G, Heidari Shirin, Wolf Hans, Frachette Marie-Joelle, Bieler Kurt, Sheppard Neil, Harari Alexandre, Bart Pierre-Alexandre, Liljeström Peter, Wagner Ralf, Pantaleo Giuseppe, Heeney Jonathan L
Abstract excerpt
Rhesus macaques (Macaca mulatta) have played a valuable role in the development of human immunodeficiency virus (HIV) vaccine candidates prior to human clinical trials. However, changes and/or improvements in immunogen quality in the good manufacturing practice (GMP) process or changes in adjuvants, schedule, route, dose, or readouts have compromised the direct comparison of T-cell responses between species. Here...
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