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Article

HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth.

Journal of virology - 15 Aug 2017

Balamurugan Arumugam, Claiborne Deon, Ng Hwee L, Yang Otto O

Abstract excerpt

Mutational escape of HIV-1 from HIV-1-specific CD8+ T lymphocytes (CTLs) is a major barrier for effective immune control. Each epitope typically is targeted by multiple clones with distinct T cell receptors (TCRs). While the clonal repertoire may be important for containing epitope variation, determinants of its composition are poorly understood. We investigate the clonal repertoire of 29 CTL responses against 23...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to HIV Infections

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 28592539
DOI: 10.1128/JVI.00771-17
PMCID: PMC5533926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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