Article

Within-host viral evolution varies with T cell receptor repertoire diversity independently of viral mutation rates

2025-05-24

Abstract excerpt

The specific T cell receptors (TCRs) present in an individual determine which antigens can be recognized, and hence a repertoire comprised of a vast number of unique TCRs ensures an effective T cell response can be mounted against a broad range of potential pathogens encountered. To evade the T cell response, pathogens, and viruses in particular, can accrue epitope escape mutations, establishing a host-pathogen 't...

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Identifiers and source

Literature Corpus work: 9270ec13-8f66-55eb-b929-3adff2470263
DOI: 10.1101/2025.05.19.654678

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