Article
Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jan 2018
Driesen M, Kondo Y, de Jong B C, Torrea G, Asnong S, Desmaretz C, Mostofa K S M, Tahseen S, Whitfield M G, Cirillo D M, Miotto P, Cabibbe A M, Rigouts L
Abstract excerpt
OBJECTIVES: The development of rapid molecular diagnostic assays for pyrazinamide (PZA) resistance is considered technically challenging as mutations are highly diverse, scattered along the full length of the pncA gene and not all are associated with PZA resistance. We evaluated the performance of the novel Genoscholar PZA-TB II line probe assay (PZA-LPA2; NIPRO Corporation, Japan). METHODS: To evaluate the...
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