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Article

Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor.

The Journal of biological chemistry - 4 Aug 2017

Mowrey David D, Xu Le, Mei Yingwu, Pasek Daniel A, Meissner Gerhard, Dokholyan Nikolay V

Abstract excerpt

The type 1 ryanodine receptor (RyR1) mediates Ca2+ release from the sarcoplasmic reticulum to initiate skeletal muscle contraction and is associated with muscle diseases, malignant hyperthermia, and central core disease. To better understand RyR1 channel function, we investigated the molecular mechanisms of channel gating and ion permeation. An adequate model of channel gating requires accurate, high-resolution...

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Identifiers

PMID: 28584051
DOI: 10.1074/jbc.M116.760199
PMCID: PMC5546034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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