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Article

Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study.

PloS one - 1 Jan 2015

Nishijima Takeshi, Hayashida Tsunefusa, Kurosawa Takuma, Tanaka Noriko, Oka Shinichi, Gatanaga Hiroyuki

Abstract excerpt

OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNP) of drug transporter proteins for TDF is a risk factor for TDF-related renal function decrement. METHODS: This study investigated the association between 3 SNPs (ABCC2-24, 1249, and ABCB1 2677), which are shown to be associated with TDF-induced tubulopathy, and clinically important renal outcomes (>10ml/min/1.73m2 decrement in eGFR relative to...

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Share to Anti-HIV Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerular Filtration Rate

Share to Kidney Diseases

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 26535588
DOI: 10.1371/journal.pone.0141931
PMCID: PMC4633171

Genes

ABCB1
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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