Article
No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Lupton Michelle K, Benyamin Beben, Proitsi Petroula, Nyholt Dale R, Ferreira Manuel A, Montgomery Grant W, Heath Andrew C, Madden Pamela A, Medland Sarah E, Gordon Scott D, Lovestone Simon, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Powell John F, Bush Ashley I, Wright Margaret J, Martin Nicholas G, Whitfield John B
Abstract excerpt
Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.