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Article

Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort.

Neurobiology of aging - 1 May 2020

Vance Elizabeth, Gonzalez Murcia Josue D, Miller Justin B, Staley Lyndsay, Crane Paul K, Mukherjee Shubhabrata, Kauwe John S K

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene,...

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Identifiers

PMID: 32143980
DOI: 10.1016/j.neurobiolaging.2020.01.013
PMCID: PMC7206870

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Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort.PMID 32143980Read ↗

Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer’s disease in large cohortSemantic proximity Read ↗

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.Semantic proximity Read ↗

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HFE mutations and Alzheimer's diseaseSemantic proximity Read ↗

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis ProjectSemantic proximity Read ↗

Meta-analysis on the association between the TF gene rs1049296 and AD.Semantic proximity Read ↗

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