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Article

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation.

Neurobiology of aging - 1 Apr 2014

Crespo Ângela C, Silva Bruno, Marques Liliana, Marcelino Erica, Maruta Carolina, Costa Sónia, Timóteo Angela, Vilares Arminda, Couto Frederico Simões, Faustino Paula, Correia Ana Paula, Verdelho Ana, Porto Graça, Guerreiro Manuela, Herrero Ana, Costa Cristina, de Mendonça Alexandre, Costa Luciana, Martins Madalena

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia in the elderly individuals, resulting from a complex interaction between environmental and genetic factors. Impaired brain iron homeostasis has been recognized as an important mechanism underlying the pathogenesis of this disease. Nevertheless, the knowledge gathered so far at the systemic level is clearly insufficient. Herein, we used an integrative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24199959
DOI: 10.1016/j.neurobiolaging.2013.10.078

Genes

TFR2
ACO1
TFRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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