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Article

Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia.

Redox biology - 1 Oct 2017

Sun Xiaolei, Zhu Hong, Dong Zhen, Liu Xiangwei, Ma Xin, Han Shasha, Lu Fei, Wang Peng, Qian Sanli, Wang Cong, Shen Cheng, Zhao Xiaona, Zou Yunzeng, Ge Junbo, Sun Aijun

Abstract excerpt

The autologous ALDH bright (ALDHbr) cell therapy for ischemic injury is clinically safe and effective, while the underlying mechanism remains elusive. Here, we demonstrated that the glycolysis dominant metabolism of ALDHbr cells is permissive to restore blood flow in an ischemic hind limb model compared with bone marrow mononuclear cells (BMNCs). PCR array analysis showed overtly elevated Aldh2 expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28582728
DOI: 10.1016/j.redox.2017.05.018
PMCID: PMC5458766

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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