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Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence

16 Dec 2021

Abstract excerpt

During embryonic development, hematopoiesis occurs through primitive and definitive waves, giving rise to distinct blood lineages. Hematopoietic stem cells (HSCs) emerge from hemogenic endothelial (HE) cells, through endothelial‐to‐hematopoietic transition (EHT). In the adult, HSC quiescence, maintenance, and differentiation are closely linked to changes in metabolism. However, metabolic processes underlying the...

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PMID: 34914165
DOI: 10.15252/embr.202154384

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