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Article

Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2015

Dollé Laurent, Boulter Luke, Leclercq Isabelle A, van Grunsven Leo A

Abstract excerpt

High aldehyde dehydrogenase (ALDH) activity is a feature of stem cells from normal and cancerous tissues and a reliable universal marker used to isolate them. There are numerous ALDH isoforms with preferred substrate specificity variably expressed depending on tissue, cell type, and organelle and cell status. On the other hand, a given substrate may be metabolized by several enzyme isoforms. Currently ALDH...

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Identifiers

PMID: 25656041
DOI: 10.1152/ajpgi.00420.2014
PMCID: PMC4385895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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