Phenotypic characterization of disease-initiating stem cells in JAK2- or CALR-mutated myeloproliferative neoplasms.

doi:10.1002/ajh.26889

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Article

Phenotypic characterization of disease-initiating stem cells in JAK2- or CALR-mutated myeloproliferative neoplasms.

American journal of hematology - 1 May 2023

Ivanov Daniel, Milosevic Feenstra Jelena D, Sadovnik Irina, Herrmann Harald, Peter Barbara, Willmann Michael, Greiner Georg, Slavnitsch Katharina, Hadzijusufovic Emir, Rülicke Thomas, Dahlhoff Maik, Hoermann Gregor, Machherndl-Spandl Sigrid, Eisenwort Gregor, Fillitz Michael, Sliwa Thamer, Krauth Maria-Theresa, Bettelheim Peter, Sperr Wolfgang R, Koller Elisabeth, Pfeilstöcker Michael, Gisslinger Heinz, Keil Felix, Kralovics Robert, Valent Peter

Abstract excerpt

Myeloproliferative neoplasms (MPN) are characterized by uncontrolled expansion of myeloid cells, disease-related mutations in certain driver-genes including JAK2, CALR, and MPL, and a substantial risk to progress to secondary acute myeloid leukemia (sAML). Although behaving as stem cell neoplasms, little is known about disease-initiating stem cells in MPN. We established the phenotype of putative CD34+ /CD38-...

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PMID: 36814396
DOI: 10.1002/ajh.26889
PMCID: PMC10952374

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