Article
Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment.
Leukemia - 1 Jun 2020
Caye Aurélie, Rouault-Pierre Kevin, Strullu Marion, Lainey Elodie, Abarrategi Ander, Fenneteau Odile, Arfeuille Chloé, Osman Jennifer, Cassinat Bruno, Pereira Sabrina, Anjos-Afonso Fernando, Currie Erin, Ariza-McNaughton Linda, Barlogis Vincent, Dalle Jean-Hugues, Baruchel André, Chomienne Christine, Cavé Hélène, Bonnet Dominique
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a rare aggressive myelodysplastic/myeloproliferative neoplasm of early childhood, initiated by RAS-activating mutations. Genomic analyses have recently described JMML mutational landscape; however, the nature of JMML-propagating cells (JMML-PCs) and the clonal architecture of the disease remained until now elusive. Combining genomic (exome, RNA-seq), Colony forming assay...
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