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Article

Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm-blast phase.

JCI insight - 22 Apr 2022

Wang Xiaoli, Rampal Raajit K, Hu Cing Siang, Tripodi Joseph, Farnoud Noushin, Petersen Bruce, Rossi Michael R, Patel Minal, McGovern Erin, Najfeld Vesna, Iancu-Rubin Camelia, Lu Min, Davis Andrew, Kremyanskaya Marina, Weinberg Rona Singer, Mascarenhas John, Hoffman Ronald

Abstract excerpt

Chronic myeloproliferative neoplasms (MPN) frequently evolve to a blast phase (BP) that is almost uniformly resistant to induction chemotherapy or hypomethylating agents. We explored the functional properties, genomic architecture, and cell of origin of MPN-BP initiating cells (IC) using a serial NSG mouse xenograft transplantation model. Transplantation of peripheral blood mononuclear cells (MNC) from 7 of 18...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35259128
DOI: 10.1172/jci.insight.156534
PMCID: PMC9089790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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