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Article

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.

Development (Cambridge, England) - 1 Aug 2014

Firulli Beth A, Fuchs Robyn K, Vincentz Joshua W, Clouthier David E, Firulli Anthony B

Abstract excerpt

In this study we examine the consequences of altering Hand1 phosphoregulation in the developing neural crest cells (NCCs) of mice. Whereas Hand1 deletion in NCCs reveals a nonessential role for Hand1 in craniofacial development and embryonic survival, altering Hand1 phosphoregulation, and consequently Hand1 dimerization affinities, in NCCs results in severe mid-facial clefting and neonatal death. Hand1...

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Identifiers

PMID: 25053435
DOI: 10.1242/dev.107680
PMCID: PMC4197675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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