Article
RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice.
Cell death and differentiation - 1 Aug 2017
Liu Yongbo, Fan Cunxian, Zhang Yifan, Yu Xianjun, Wu Xiaoxia, Zhang Xixi, Zhao Qun, Zhang Haiwei, Xie Qun, Li Ming, Li Xiaoming, Ding Qiurong, Ying Hao, Li Dali, Zhang Haibing
Abstract excerpt
RIP1 is an essential regulator of TNF-induced signaling complexes mediating NF-κB activation, apoptosis and necroptosis. Loss of Rip1 rescues the embryonic lethality of Fadd or Caspase-8-deficient mice, even though the double knockout mice die shortly after birth like Rip1-deficient mice. Recent studies demonstrated that mice expressing RIP1 kinase-dead mutants developed normally and resisted necroptotic stimuli...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.