Article

Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development

2021-07-26

Abstract excerpt

<title>Abstract</title> <p>ABIN1 is a polyubiquitin-binding protein known to regulate NF-κB activation and cell death signaling. Mutations in <italic>Abin1</italic> can cause severe immune diseases in human, such as psoriasis, systemic lupus erythematosus, and systemic sclerosis. Here, we generated mice that disrupted the ubiquitin-binding domain of ABIN1 (<italic>Abin1</italic><sup><italic>UBD/UBD</italic></sup>...

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Literature Corpus work: 2f6cdd45-f733-556d-b49d-112fa8e161ea
DOI: 10.21203/rs.3.rs-712049/v1

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