Article
Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.
The Journal of biological chemistry - 27 Apr 2012
Duprez Linde, Bertrand Mathieu J M, Vanden Berghe Tom, Dondelinger Yves, Festjens Nele, Vandenabeele Peter
Abstract excerpt
Receptor-interacting protein kinase 1 (RIPK1) is an important component of the tumor necrosis factor receptor 1 (TNFR1) signaling pathway. Depending on the cell type and conditions, RIPK1 mediates MAPK and NF-κB activation as well as cell death. Using a mutant form of RIPK1 (RIPK1ΔID) lacking the intermediate domain (ID), we confirm the requirement of this domain for activation of these signaling events....
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