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Article

Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward- and outward-facing conformational states.

The Journal of biological chemistry - 21 Jul 2017

Giladi Moshe, van Dijk Liat, Refaeli Bosmat, Almagor Lior, Hiller Reuben, Man Petr, Forest Eric, Khananshvili Daniel

Abstract excerpt

Na+/Ca2+ exchanger (NCX) proteins operate through the alternating access mechanism, where the ion-binding pocket is exposed in succession either to the extracellular or the intracellular face of the membrane. The archaeal NCX_Mj (Methanococcus jannaschii NCX) system was used to resolve the backbone dynamics in the inward-facing (IF) and outward-facing (OF) states by analyzing purified preparations of apo- and...

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Identifiers

PMID: 28572509
DOI: 10.1074/jbc.M117.787168
PMCID: PMC5519378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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