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Article

Structure-affinity insights into the Na+ and Ca2+ interactions with multiple sites of a sodium-calcium exchanger.

The FEBS journal - 1 Nov 2020

Iwaki Masayo, Refaeli Bosmat, van Dijk Liat, Hiller Reuben, Giladi Moshe, Kandori Hideki, Khananshvili Daniel

Abstract excerpt

Selective recognition and transport of Na+ and Ca2+ ions by sodium-calcium exchanger (NCX) proteins is a primary prerequisite for Ca2+ signaling and homeostasis. Twelve ion-coordinating residues are highly conserved among NCXs, and distinct NCX orthologs contain two or three carboxylates, while sharing a common ion-exchange stoichiometry (3Na+ :1Ca2+ ). How these structural differences affect the ion-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32056381
DOI: 10.1111/febs.15250

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