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Article

Characterization of the Cation Binding Sites in the NCKX2 Na+/Ca2+-K+ Exchanger.

Biochemistry - 22 Nov 2016

Zhekova Hristina, Zhao Chunfeng, Schnetkamp Paul P M, Noskov Sergei Yu

Abstract excerpt

NCKX1-5 are proteins involved in K+-dependent Na+/Ca2+ exchange in various signal tissues. Here we present a homology model of NCKX2 based on the crystal structure of the NCX_Mj transporter found in Methanoccocus jannaschii. Molecular dynamics simulations were performed on the resultant wild-type NCKX2 model and two mutants (D548N and D575N) loaded with either four Na+ ions or one Ca2+ ion and one K+ ion, in line...

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PMID: 27805378
DOI: 10.1021/acs.biochem.6b00591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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