Article
Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.
International journal of molecular sciences - 22 Nov 2016
Giladi Moshe, Shor Reut, Lisnyansky Michal, Khananshvili Daniel
Abstract excerpt
The membrane-bound sodium-calcium exchanger (NCX) proteins shape Ca2+ homeostasis in many cell types, thus participating in a wide range of physiological and pathological processes. Determination of the crystal structure of an archaeal NCX (NCX_Mj) paved the way for a thorough and systematic investigation of ion transport mechanisms in NCX proteins. Here, we review the data gathered from the X-ray...
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