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Article

Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.

Journal of the American Chemical Society - 2 Nov 2016

Seetoh Wei-Guang, Abell Chris

Abstract excerpt

Identifying small molecules that induce the disruption of constitutive protein-protein interfaces is a challenging objective. Here, a targeted biophysical screening cascade was employed to specifically identify small molecules that could disrupt the constitutive, homodimeric protein-protein interface within CK2β. This approach could potentially be applied to achieve subunit disassembly of other homo-oligomeric...

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Identifiers

PMID: 27726344
DOI: 10.1021/jacs.6b07440
PMCID: PMC5257173

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