Article
Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating.
Neuron - 16 Sept 2004
Bildl Wolfgang, Strassmaier Tim, Thurm Henrike, Andersen Jens, Eble Silke, Oliver Dominik, Knipper Marlies, Mann Matthias, Schulte Uwe, Adelman John P, Fakler Bernd
Abstract excerpt
Small conductance Ca(2+)-activated K+ channels (SK channels) couple the membrane potential to fluctuations in intracellular Ca2+ concentration in many types of cells. SK channels are gated by Ca2+ ions via calmodulin that is constitutively bound to the intracellular C terminus of the channels and serves as the Ca2+ sensor. Here we show that, in addition, the cytoplasmic N and C termini of the channel protein form...
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