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Article

A role for Pin1 in mammalian germ cell development and spermatogenesis.

Frontiers in bioscience : a journal and virtual library - 1 Sept 2004

Atchison Fawn W, Means Anthony R

Abstract excerpt

The peptidyl-prolyl isomerase Pin1 is proposed to have diverse functions in many vital aspects of the cell. Despite the multitude of proteins targeted by Pin1 and the proposed regulatory role it plays in critical cellular functions, Pin1 is an essential gene in some eukaryotic organisms, but is dispensable in metazoans. In two genetic models, Candida albicans and Drosophila melanogaster, Pin1 participates in...

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Identifiers

PMID: 15353353
DOI: 10.2741/1476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A role for Pin1 in mammalian germ cell development and spermatogenesis.PMID 15353353Read ↗

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.Semantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

Spermatogonial Depletion in Adult Pin1-Deficient Mice1Semantic proximity Read ↗

Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell FunctionSemantic proximity Read ↗

Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future DirectionsSemantic proximity Read ↗

The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55Semantic proximity Read ↗

The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1Semantic proximity Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.Semantic proximity Read ↗

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.Semantic proximity Read ↗

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